Diphenyl Ether → HCID 13548681, compound

Reaction equation

C([O:3][C:4](=O)[NH:5][N:6]=[CH:7][C:8]1[N:9]=[C:10]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[NH:11][C:12]=1[CH3:13])C.C1(OC2C=CC=CC=2)C=CC=CC=1>>[CH3:13][C:12]1[N:11]=[C:10]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:9]2[C:8]=1[CH:7]=[N:6][NH:5][C:4]2=[O:3]

Participants

Reactant 2

HCID 7583Diphenyl Ether

HCID 136138544HCID 136138544, compound

Product 1

HCID 13548681HCID 13548681, compound

Procedure

An 8.33 gm. portion of 3-[(5-methyl-2-phenyl-4-imidazolyl)methylene]carbazic acid ethyl ester in 60 ml. of diphenyl ether is heated in an oil bath at 215°-230° C. for 20 minutes. The reaction mixture is diluted to 400 ml. with petroleum ether. The precipitate is collected and recrystallized from 350 ml. of benzene giving the desired product, m.p. 182°-184.5° C.

Workup

additionThe reaction mixture is diluted to 400 ml
customThe precipitate is collected
customrecrystallized from 350 ml

Sources & evidence

ORD record: ord-bd68faf660064b3f9941d962b113f693
Source dataset: uspto-grants-1978_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04124766

Reaction notes

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