Hydrogen Bromide → HCID 86736145, compound
Reaction equation
[I:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:12])[CH2:9][CH2:10]O)=[CH:4][CH:3]=1.Br.NC(N)=[S:16]>O>[I:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:12])[CH2:9][CH2:10][SH:16])=[CH:4][CH:3]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
70 g of 3-(p-iodophenyl) butanol was combined in solution with 138 g of hydrobromic acid (48%) and 20 g thiourea in 100 ml of water and the thiol product vacuum distilled at 126° and 0.18 mm Hg. A 41% yield of 3-(p-Iodophenyl) butane thiol was confirmed having a refractive index of n25D = 1.6071 and nmr, ir and gc readings commensurate with the structure of the desired product.
Workup
- distillationthe thiol product vacuum distilled at 126°
Sources & evidence
- ORD record
- ord-a570eb0d6d32463ab7ca54be87b9cf08
- Source dataset
- uspto-grants-1978_11
- Patent number
- US04125554
Reaction notes
Loading…