Reaction equation
Br[CH:2]([C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:15]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:17]=[CH:18][CH:19]=2)=[CH:9][CH:8]=1)[C:3]([O:5][CH3:6])=[O:4].[Cl:24][C:25]1[CH:30]=[CH:29][C:28]([OH:31])=[CH:27][CH:26]=1>>[Cl:24][C:25]1[CH:30]=[CH:29][C:28]([O:31][CH:2]([C:7]2[CH:12]=[CH:11][C:10]([O:13][C:14]3[CH:15]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:17]=[CH:18][CH:19]=3)=[CH:9][CH:8]=2)[C:3]([O:5][CH3:6])=[O:4])=[CH:27][CH:26]=1Participants
3
Procedure
In a manner similar to Example 16, 7.62 g of methyl α-bromo-α-[p-(α,α,α-trifluoro-m-tolyloxy)phenyl]acetate was reacted with 3.21 g of p-chlorophenol to give a gel which crystallized on trituration with 50 ml of petroleum ether (6.45 g). Recrystallization from 50 ml of hexane yielded a 5.8 g of a white solid, mp 79°-82° C.
Workup
- customto give a gel which
- customcrystallized on trituration with 50 ml of petroleum ether (6.45 g)
- customRecrystallization from 50 ml of hexane
Sources & evidence
- ORD record
- ord-c80bac50ca424577ac87652550cc7b7f
- Source dataset
- uspto-grants-1978_11
- Patent number
- US04125729
Linked notes
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