Dichloromethane → 5-Chloro-2-methoxybenzoyl chloride

HRID 1706484

Reaction equation

HRID 1706484 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:22][CH3:23])=[C:6]([CH:21]=1)[C:7]([NH:9][CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][OH:20])=[CH:14][CH:13]=1)=[O:8].C(N(CC)CC)C.C(Cl)[Cl:32]>>[NH2:9][CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][OH:20])=[CH:14][CH:13]=1.[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:22][CH3:23])=[C:6]([CH:21]=1)[C:7]([Cl:32])=[O:8]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 234531155-Chloro-N-{2-[4-(2-hydroxyethyl)phenyl]ethyl}-2-methoxybenzamide

Product 2

HCID 123841765-Chloro-2-methoxybenzoyl chlorideHCID 218318414-(2-Hydroxyethyl)-phenethylamine

Procedure

The 2-{4-[2-(5-chloro-2-methoxybenzamido)-ethyl]-phenyl}-ethanol (oil) used as starting material is obtained by the acylation of 2-[4-(2-aminoethyl)-phenyl]-ethanol (oil) with 5-chloro-2-methoxybenzoyl chloride in anhydrous methylene chloride in the presence of triethylamine as acid acceptor.

Sources & evidence

ORD record
ord-59164c5477194e0b9420b1506022f10b
Source dataset
uspto-grants-1980_06
Patent number
US04207341

Linked notes

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