Pyridine → 2-Hydrazino-5-phenylpyrimidine
Reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][N:3]=1.N1C=CC=CC=1.O.[NH2:21][NH2:22]>O>[NH:21]([C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][N:3]=1)[NH2:22]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 5.4 g. of 2-chloro-5-phenylpyrimidine in 25 ml. of pyridine is added 25 ml. of hydrazine hydrate. The mixture is heated on a steam bath for one hour with occasional swirling. Water is added and the material that is separated is collected and crystallized from methanol to give 4.5 g. of the product of the Example, m.p. 155° C.
Workup
- temperatureThe mixture is heated on a steam bath for one hour
- customthe material that is separated
- customis collected
- customcrystallized from methanol
- customto give 4.5 g
Sources & evidence
- ORD record
- ord-0dedac35560640c38892fcf397a01082
- Source dataset
- uspto-grants-1980_06
- Patent number
- US04209621
Reaction notes
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