Magnesium orthosilicate → 1-(2-Chlorophenyl)-3-(dimethylamino)prop-2-en-1-one
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:10])[CH3:9].CO[CH:13](OC)[N:14]([CH3:16])[CH3:15].[Si]([O-])([O-])([O-])[O-].[Mg+2].[Mg+2]>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:10])[CH:9]=[CH:13][N:14]([CH3:16])[CH3:15]Participants
5
Procedure
A mixture of 25 g. of o-chloroacetophenone and 25 ml. of dimethylformamide dimethylacetal is refluxed for 16 hours. Evaporation gives a thick red-brown oil which is dissolved in methylene chloride and this solution passed through a hydrous magnesium silicate column. Evaporation of solvent gives an oil which is then purified by bulb to bulb distillation.
Workup
- additionA mixture of 25 g
- customEvaporation
- customgives a thick red-brown oil which
- customEvaporation of solvent
- customgives an oil which
- distillationis then purified by bulb to bulb distillation
Sources & evidence
- ORD record
- ord-1228b0cf159c45249af43320a28bea3e
- Source dataset
- uspto-grants-1980_06
- Patent number
- US04209621
Reaction notes
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