Butaclamol → Dopamine

HRID 1712869

Reaction equation

HRID 1712869 reaction equation
C[N:2]1[CH2:12][C@H:11](C2C=CC=CC=2)[C:10]2[CH:9]=[C:8]([OH:19])[C:7](Cl)=[CH:6][C:5]=2CC1.CC([C@]1([OH:47])C[C@H]2N(C[C@H]3C4C2=CC=CC=4CCC2C=CC=CC3=2)CC1)(C)C>>[NH2:2][CH2:12][CH2:11][C:10]1[CH:5]=[CH:6][C:7]([OH:47])=[C:8]([OH:19])[CH:9]=1

Participants

3

Reactant 2

HCID 37461ButaclamolHCID 3036864R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol

Product 1

HCID 681Dopamine

Procedure

HEK cells were transfected with DNA encoding D1-NLS-GFP (2 micrograms), and D1-WT (6 micrograms) for 48 hours. These cells were treated 6 hrs after transfection with SCH-23390 (10 micromolar), or (+)butaclamol (10 micromolar). The medium containing antagonist was changed at 6, 22, 30 and 42 hours after transfection. Control cells received no antagonist treatment.

Workup

  1. additionThe medium containing antagonist
  2. customwas changed at 6, 22, 30 and 42 hours

Sources & evidence

ORD record
ord-a3f9fc04036e44f4afbc9730448073af
Source dataset
uspto-grants-2010_09
Patent number
US07794955B2

Linked notes

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