Basic information
- CAS
87075-17-0- Standard SMILES
CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1- InChIKey
GOTMKOSCLKVOGG-OAHLLOKOSA-N- Molecular formula
- C17H18ClNO
- Average molar mass
- 287.8 g/mol
- Monoisotopic mass
- 287.10769188
Overview
(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol is a benzazepine.
Names & identifiers
- Preferred name
- R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol
- IUPAC
- (5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol
- English name
- Sch-23390
- Molecular formula
- C17H18ClNO
- Molecular weight
- 287.78
Names & synonyms
RefChem:930510R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol87075-17-0SCH-23390(R)-2,3,4,5-Tetrahydro-8-chloro-3-methyl-5-phenyl-1H-3-benzazepin-7-olUNII-UGT5535REQ(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-olSCH 23390CHEMBL62UGT5535REQR-(+)-SCH 233901H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-, (R)-
Show more names
(+)-SCH23390(+)-7-Chloro-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepin-8-ol(5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol
Sch 23388(R)-8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-, (5R)-SCH23390GOTMKOSCLKVOGG-OAHLLOKOSA-NR-(+)-SCH-23390Tocris-0925Biomol-NT_000016
Database identifiers
- CAS
Properties
Computed structural properties
- XLogP
- 4
- Topological polar surface area
- 23.5 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 1
- Heavy atoms
- 20
- Formal charge
- 0
- Complexity
- 318
Experimental & physicochemical properties
LogP2.87
Physicochemical properties
- Boiling point
- 414.7 · 414.7±45.0 °C(Predicted)
- Density
- 1.2 · 1.200±0.06 g/cm3(Predicted)
- pka
- 8.83 · 8.83±0.40(Predicted)
- FDA UNII
- 5535 REQ · UGT5535REQ
Chemistry & industry
Applications
UsesSCH-23390 is a dopamine D1-like receptor antagonist (with Ki values of 0.2 nM and 0.3 nM for the D1 and D5 receptor subtypes, respectively). SCH-23390 can shorten the latency period for cocaine-induced lever pressing behavior in rats. SCH-23390 can also eliminate generalized seizures caused by chemical convulsants, such as arecoline (HY-B0726A) and strychnine, and is used in research on neurological disorders related to the dopamine system[1][2].
Suppliers4 total
上海摩睿化学科技有限公司13382110328 15255501563 · [email protected]
TargetMol 中国（陶术生物）400-821-0310 15002144251 · [email protected]
风咏生物（AbMole）021-10000000 13000000000 · [email protected]
上海超岚化工科技中心QQ：65489617 13301690235 · [email protected]
Additional notes
DefinitionChEBI: (5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol is a benzazepine.
Related reactions
6 records
Compound notes
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