Hydrochloric Acid → 2-(6-methylpyridazin-3-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine hydrochloride
Reaction equation
[CH3:1][C:2]1[N:7]=[N:6][C:5]([N:8]2[CH:23]=[C:11]3[CH2:12][N:13](C(OC(C)(C)C)=O)[CH2:14][CH2:15][C:10]3=[N:9]2)=[CH:4][CH:3]=1.[ClH:24]>O1CCOCC1>[ClH:24].[CH3:1][C:2]1[N:7]=[N:6][C:5]([N:8]2[CH:23]=[C:11]3[CH2:12][NH:13][CH2:14][CH2:15][C:10]3=[N:9]2)=[CH:4][CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of tert-butyl 2-(6-methylpyridazin-3-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate (2.38 g, 7.55 mmol) in dioxane (20 ml) is added 4N HCl in dioxane (20 mL, 80 mmol) and the mixture is stirred at rt overnight. The solvent is removed and the residue is washed with ether to give the title compound as a white solid. MS (M+1): 216.2.