Triethylamine → HCID 86594426, compound

A mixture of (S)-2-tert-butoxycarbonylamino-4-iodobutyric acid methyl ester (0.200 g, 0.58 mmol), (2-methoxyethyl)-methylamine (0.062 g, 0.70 mmol), and triethylamine (0.41 mL, 2.9 mmol) in dioxane (1 mL) was stirred at 70° C. for 16 hours. The mixture was cooled to room temperature, concentrated under reduced pressure, and dissolved in dichloromethane (20 mL). The solution was washed with water (3×10 mL), brine (10 mL), dried over MgSO4, filtered through Celite, and concentrated under reduced pressure. The tan oil was chromatographed eluting with ether to provide 0.87 g of pale yellow oil (49% yield).

1. temperatureThe mixture was cooled to room temperature
2. concentrationconcentrated under reduced pressure
3. dissolutiondissolved in dichloromethane (20 mL)
4. washThe solution was washed with water (3×10 mL), brine (10 mL)
5. dry with materialdried over MgSO4
6. filtrationfiltered through Celite
7. concentrationconcentrated under reduced pressure
8. customThe tan oil was chromatographed
9. washeluting with ether

ORD record

ord-ac6900bde4a04d5d9588f0e8768d521e

Source dataset

uspto-grants-2010_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07799782B2