Hydroxyamine hydrochloride → HCID 178492604, compound
Reaction equation
C([O-])(=O)C.[Na+].[CH3:6][O:7][C:8]1[CH:17]=[CH:16][C:11]([O:12][CH2:13][C:14]#[N:15])=[CH:10][CH:9]=1.Cl.[NH2:19][OH:20]>CO>[OH:20][NH:19][C:14](=[NH:15])[CH2:13][O:12][C:11]1[CH:16]=[CH:17][C:8]([O:7][CH3:6])=[CH:9][CH:10]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Add sodium acetate (5.1 g, 62 mmol) to 4-methoxyphenoxyacetonitrile (5.0 g, 31 mmol) and hydroxylamine hydrochloride (4.3 g, 62 mmol) in methanol (100 mL). Stir the resulting mixture at room temperature for 20 hours. Filter the resulting mixture through Celite, concentrate, stir in chloroform for 18 hours and filter. Concentrate the resulting solution to the title compound (5.1 g). LC-MS (m/e): 197 (M+1).
Workup
- filtrationFilter the resulting mixture through Celite
- concentrationconcentrate
- stirringstir in chloroform for 18 hours
- filtrationfilter
- concentrationConcentrate the resulting solution to the title compound (5.1 g)
Sources & evidence
- ORD record
- ord-82d7866b3bb54b5e8ddc37181928f07e
- Source dataset
- uspto-grants-2010_09
- Patent number
- US07803938B2
Reaction notes
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