Ammonium Hydroxide → Thiophen-2-acetamide

HRID 1720448

Reaction equation

HRID 1720448 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7](Cl)=[O:8].[NH4+:10].[OH-]>>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([NH2:10])=[O:8]

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 1623622-Thiopheneacetyl chloride

Product 1

HCID 78208Thiophen-2-acetamideYield 64%

Procedure

To a mixture of concentrated NH4OH (100 mL) and ice was added 2-thiopheneacetyl chloride (13.0 g, 80.9 mmol). The desired compound crystallized from the reaction mixture. Recrystallization from hot water gave 2-thiopheneacetamide (8.08 g, 64% yield) as white crystals. mp 146°-147° C.

Workup

  1. customThe desired compound crystallized from the reaction mixture
  2. customRecrystallization from hot water

Sources & evidence

ORD record
ord-9790f435c18448d485b548d5d6086422
Source dataset
uspto-grants-1996_04
Patent number
US05506261

Linked notes

Loading…