Methane → 4,5-Dihydroxy-2-nitrobenzeneacetonitrile
Reaction equation
C.[N+:2]([C:5]1[CH:10]=[C:9]([O:11]CC2C=CC=CC=2)[C:8]([O:19]CC2C=CC=CC=2)=[CH:7][C:6]=1[CH2:27][C:28]#[N:29])([O-:4])=[O:3].C1CCCCC=1>[Pd].C(O)C>[N+:2]([C:5]1[CH:10]=[C:9]([OH:11])[C:8]([OH:19])=[CH:7][C:6]=1[CH2:27][C:28]#[N:29])([O-:4])=[O:3]Participants
6
Reactant 3
Product 1
Reagents, catalysts & solvents 2
Procedure
0.75 g of palladium at a concentration of 10% on charcoal, to which 3 g of charcoal have been added, followed by 0.02 mole (7.5 g) of 2-nitro-4,5-dibenzyloxyphenylacetonitrile, are added with stirring to 30 ml of 96° C. ethanol containing 15 ml of cyclohexene; the reaction mixture is heated under reflux for 1 hour.
Workup
- additionare added
- temperaturethe reaction mixture is heated
- temperatureunder reflux for 1 hour
Sources & evidence
- ORD record
- ord-7e065de68e6a4223bb119da42d0cbb4c
- Source dataset
- uspto-grants-1996_04
- Patent number
- US05508464
Reaction notes
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