Phosphorus oxychloride → 2-chloro-7-[3-(trifluoromethyl)pyridin-2-yl]-N-[5-(trifluoromethyl) pyridin-2-yl]-[1,8]naphthyridin-4-amine
Reaction equation
[F:1][C:2]([F:32])([F:31])[C:3]1[C:4]([C:9]2[N:18]=[C:17]3[C:12]([C:13]([NH:20][C:21]4[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][N:22]=4)=[CH:14][C:15](O)=[N:16]3)=[CH:11][CH:10]=2)=[N:5][CH:6]=[CH:7][CH:8]=1.P(Cl)(Cl)([Cl:35])=O>>[Cl:35][C:15]1[CH:14]=[C:13]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][N:22]=2)[C:12]2[C:17](=[N:18][C:9]([C:4]3[C:3]([C:2]([F:32])([F:31])[F:1])=[CH:8][CH:7]=[CH:6][N:5]=3)=[CH:10][CH:11]=2)[N:16]=1Participants
3
Procedure
Heat 7-[3-(trifluoromethyl)pyridin-2-yl]-4-{[5-(trifluoromethyl)pyridin-2-yl]amino}-[1,8]naphthyridin-2-ol (112 mg) and phosphorus oxychloride (1 mL) at reflux for 1 hour. Evaporate to dryness, partition between ethyl acetate and saturated aqueous NaHCO3 and extract with EtOAc. Dry the combined organics over Na2SO4, concentrate under vacuum to obtain the title compound.
Workup
- temperatureat reflux for 1 hour
- customEvaporate to dryness