Lactulose → Lactitol Monohydrate

HRID 1727

Reaction equation

HRID 1727 reaction equation
[CH2:1]([OH:23])[C@H:2]1[O:7][C@@H:6]([O:8][C@@H:9]([C@H:14]([OH:19])[C@@H:15]([OH:18])[CH2:16][OH:17])[C@H:10]([OH:13])[CH2:11][OH:12])[C@H:5]([OH:20])[C@@H:4]([OH:21])[C@H:3]1[OH:22].O.O.C(O)[C@H]1[O:32][C@@H](O[C@H]2[C@H](O)[C@@](O)(CO)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O>O>[CH2:1]([OH:23])[C@H:2]1[O:7][C@@H:6]([O:8][C@@H:9]([C@H:14]([OH:19])[C@@H:15]([OH:18])[CH2:16][OH:17])[C@H:10]([OH:13])[CH2:11][OH:12])[C@H:5]([OH:20])[C@@H:4]([OH:21])[C@H:3]1[OH:22].[OH2:32]

Participants

4

Reactant 2

HCID 11333Lactulose2×HCID 157354Lactitol dihydrate

Product 1

HCID 3067270Lactitol MonohydrateYield 4.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

950 g lactitol dihydrate (860 g anhydric lactitol) were dissolved in 125 g water at 100° C. Upon cooling to 50° C. the 80 percent by weight lactitol solution was seeded with 9.5 g ground dihydrate (1 percent by weight based on the lactitol dissolves). After crystallization for 48 hours at 45° C. the crystals formed were separated from the mother liqouor in a laboratory centrifuge, washed with 25 ml water and dried at 45° C. (drying cabinet). There were then obtained 440 g lactitol monohydrate (melting point: 118°-120° C.; moisture content: 4.9%) or 49% based on the lactitol used.

Workup

  1. dissolutiondissolves)
  2. customAfter crystallization for 48 hours at 45° C. the crystals
  3. customformed
  4. customwere separated from the mother liqouor in a laboratory centrifuge
  5. washwashed with 25 ml water
  6. customdried at 45° C.
  7. custom(drying cabinet)

Sources & evidence

ORD record
ord-19ef8b5233de4220a1842b9d3ce2334f
Source dataset
uspto-grants-1998_03
Patent number
US05726303

Linked notes

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