Hydroxylamine → HCID 19017744, compound

Reaction equation

[CH3:1][C:2]1[O:6][N:5]=[CH:4][C:3]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8].[C:12]1(S(OCCC)(=O)=O)[CH:17]=CC=C[CH:13]=1.[NH2:25]O>>[CH3:1][C:2]1[O:6][N:5]=[C:4]([NH:25][CH2:13][CH2:12][CH3:17])[C:3]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8]

Participants

Reactant 3

HCID 787Hydroxylamine

HCID 220447Propyl benzenesulfonate

HCID 7009317Ethyl 5-methylisoxazole-4-carboxylate

Product 1

HCID 19017744HCID 19017744, compound

Procedure

Ethyl 5-methylisoxazole-4-carboxylate is quaternized with propyl benzenesulfonate and the resulting quaternary salt is reacted with hydroxylamine to give the title compound according to the procedure of A. Alberola et al., Synthesis 203 (1988).

Sources & evidence

ORD record: ord-2d9b4c7d4fd34675adf80b48cf590927
Source dataset: uspto-grants-1994_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05326776

Reaction notes

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