1-(2-Methoxyphenyl)piperazine → 8-((3-(4-(2-Methoxyphenyl)piperazin-1-yl)-2-hydroxypropyl)oxy)thiochroman
Reaction equation
[O:1]1[CH2:15][CH:2]1[CH2:3][O:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[S:13][CH2:12][CH2:11][CH2:10]2.[CH3:16][O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1>O1CCCC1>[CH3:16][O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[N:24]1[CH2:29][CH2:28][N:27]([CH2:15][CH:2]([OH:1])[CH2:3][O:4][C:5]2[CH:6]=[CH:7][CH:8]=[C:9]3[C:14]=2[S:13][CH2:12][CH2:11][CH2:10]3)[CH2:26][CH2:25]1Participants
4
Procedure
140 mg (0.63 mmol) of the compound obtained in Step A are dissolved in 1.5 cm3 of anhydrous tetrahydrofuran. 600 mg (3.15 mmol) of 1-(2-methoxyphenyl)piperazine, diluted in 1.5 cm3 of anhydrous tetrahydrofuran, are added.