Benzene → HCID 12906807, compound
Reaction equation
[CH3:1][C:2]1([CH3:7])[NH:6][CH2:5][CH2:4][S:3]1.C1C=CC=CC=1.[Br:14][CH:15]([Br:19])[C:16](Cl)=[O:17].C(N(CC)CC)C>O>[CH3:1][C:2]1([CH3:7])[N:6]([C:16](=[O:17])[CH:15]([Br:19])[Br:14])[CH2:5][CH2:4][S:3]1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
To a mixture of 3.5 g. of 2,2-dimethyl thiazolidine, 50 ml. of benzene and 7.1 g. of dibromoacetyl chloride mixed in an ice bath was added 3.1 g. of triethylamine dropwise with stirring and continued cooling. When reaction was complete, the mixture was poured into water and the benzene layer separated, dried over magnesium sulfate and the benzene removed under vacuum. Yield was 8.5 g. of a dark oil.
Workup
- additionTo a mixture of 3.5 g
- additionwas added 3.1 g
- temperaturecontinued cooling
- customWhen reaction
- customthe benzene layer separated
- dry with materialdried over magnesium sulfate
- customthe benzene removed under vacuum
Sources & evidence
- ORD record
- ord-683d6c7f294c49fcb8b5e2468f1fc091
- Source dataset
- uspto-grants-1976_11
- Patent number
- US03989503
Reaction notes
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