Hydrochloric Acid → 3-(1,3,4,9b-Tetrahydro-5-methyl-2H-indeno[1,2-c]pyridin-2-yl)-N-propylpropionic acid amide

HRID 1730000

Reaction equation

[CH3:1][C:2]1[C:3]2[C:8]([CH:9]3[C:14]=1[CH2:13][CH2:12][NH:11][CH2:10]3)=[CH:7][CH:6]=[CH:5][CH:4]=2.[CH2:15]([NH:18][C:19](=[O:22])[CH:20]=[CH2:21])[CH2:16][CH3:17].Cl>>[CH3:1][C:2]1[C:3]2[C:8]([CH:9]3[C:14]=1[CH2:13][CH2:12][N:11]([CH2:21][CH2:20][C:19]([NH:18][CH2:15][CH2:16][CH3:17])=[O:22])[CH2:10]3)=[CH:7][CH:6]=[CH:5][CH:4]=2

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 114794N-(n-Propyl) acrylamide

HCID 214987881,3,4,9b-tetrahydro-5-methyl-2H-indeno[1,2-c]pyridine

Product 1

HCID 681390763-(1,3,4,9b-Tetrahydro-5-methyl-2H-indeno[1,2-c]pyridin-2-yl)-N-propylpropionic acid amide

Procedure

1,3,4,9b-Tetrahydro-5-methyl-2H-indeno[1,2-c]pyridine and N-propyl acrylamide are reacted in accordance with the process described in Example 6. Reaction period 20 hours. M.P. of the hydrochloride of the title compound 196°-197° from ethanol (decomp.).

Workup

customReaction period 20 hours

Sources & evidence

ORD record: ord-009868a82a694d1abeb2207a81ff6de5
Source dataset: uspto-grants-1976_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03991066

Linked notes

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