Thiosemicarbazide → 1-(5-Phenylvaleroyl)-3-thiosemicarbazide
Reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][C:11](Cl)=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:14][NH:15][C:16]([NH2:18])=[S:17]>CN(C)C=O>[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][C:11]([NH:14][NH:15][C:16]([NH2:18])=[S:17])=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 9.9 g. of 5-phenylvaleroylchloride and 4.6 g. of thiosemicarbazide was stirred in 20 ml. of dimethylformamide for 6 hours at 22° C. The solvent was evaporated and 10 ml. of water and 10 ml.of ether were added to the residue. The precipitate was filtered off to give the intermediate 1-(5-phenylvaleroyl)-3-thiosemicarbazide, m.p. 140°-141° C.
Workup
- additionA mixture of 9.9 g
- customThe solvent was evaporated
- additionof ether were added to the residue
- filtrationThe precipitate was filtered off
Sources & evidence
- ORD record
- ord-ab052f9e35ab41e59ff356d7ba0f136d
- Source dataset
- uspto-grants-1976_11
- Patent number
- US03992396
Reaction notes
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