Propanenitrile, 3-ethoxy- → 3-Amino-1-(5-chloro-2-pyridyl)-2-pyrazoline
Reaction equation
[Na].[Cl:2][C:3]1[CH:4]=[CH:5][C:6]([NH:9][NH2:10])=[N:7][CH:8]=1.C(O[CH2:14][CH2:15][C:16]#[N:17])C>C(O)C>[NH2:17][C:16]1[CH2:15][CH2:14][N:9]([C:6]2[CH:5]=[CH:4][C:3]([Cl:2])=[CH:8][N:7]=2)[N:10]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A 0.08 g. amount of sodium metal is dissolved in 10 ml. of absolute ethanol, then 2.5 g. of 5-chloro-2-hydrazinopyridine is added, followed by 1.70 g. of beta-ethoxypropionitrile. The procedure of Example 1 is continued to give 1.40 g. of the product of the Example as yellow crystals, m.p. 203°-204.5° C.
Workup
- customto give 1.40 g
Sources & evidence
- ORD record
- ord-0dd7695bf24943a1b0dc259beb62d8ac
- Source dataset
- uspto-grants-1986_11
- Patent number
- US04622401
Reaction notes
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