Cyanoacetamide → HCID 20300116, compound
Reaction equation
C[O-].[Na+].[C:4]([CH2:6][C:7]([NH2:9])=[O:8])#[N:5].CN(C)[CH:12]=[C:13]([C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[CH:17]=1)[CH:14]=O>CO>[CH3:22][C:18]1[CH:17]=[C:16]([C:13]2[CH:14]=[C:6]([C:4]#[N:5])[C:7](=[O:8])[NH:9][CH:12]=2)[CH:21]=[CH:20][CH:19]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
In the manner described in Example 6, a solution of 13.7 g. of sodium methoxide and 10.7 g. of cyanoacetamide in 250 ml. of methanol and 24.0 g. of 3-(dimethylamino)-2-(3-methylphenyl)-2-propenal is refluxed overnight to give 12.0 g. of the product of the Example as a yellow solid, m.p. 254.5°-260° C.
Workup
- customto give 12.0 g
Sources & evidence
- ORD record
- ord-d1c2d92976b349c883d8c730455c818f
- Source dataset
- uspto-grants-1980_12
- Patent number
- US04242515
Reaction notes
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