Hydrochloric Acid → HCID 15818098, compound
Reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[C:5]([CH:15]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:17]=1)[CH2:6][P:7](=[O:14])([O:11]CC)[O:8]CC.Cl>C(O)C>[F:23][C:2]([F:1])([F:22])[C:3]1[CH:4]=[C:5]([CH:15]=[C:16]([C:18]([F:21])([F:19])[F:20])[CH:17]=1)[CH2:6][P:7](=[O:8])([OH:11])[OH:14]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Diethyl 3,5-bis(trifluoromethyl)benzylphosphonate (1.0 g, 2.7 mmol)in 15 mL of cone hydrochloric acid and 0.5 mL of ethanol was heated at reflux for 72 hours. The mixture was evaporated to an oily residue which crystallized upon standing to give 0.41 g of the product (49% yield) the as a white solid: mp. 206°-208° C.; D.C.I.M.S. [MH+, 309].
Workup
- temperatureat reflux for 72 hours
- customThe mixture was evaporated to an oily residue which
- customcrystallized
Sources & evidence
- ORD record
- ord-ab1775352ed14f9eb7fa44fb14b1e40f
- Source dataset
- uspto-grants-1996_07
- Patent number
- US05532226
Reaction notes
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