Hydrochloric Acid → 1-[3-(aminomethyl)phenyl]ethan-1-one hydrochloride
Reaction equation
[CH3:1][C:2]1([C:7]2[CH:8]=[C:9]([CH:12]=[CH:13][CH:14]=2)[CH2:10][NH2:11])OCC[O:3]1.[ClH:15]>CO>[ClH:15].[C:2]([C:7]1[CH:8]=[C:9]([CH:12]=[CH:13][CH:14]=1)[CH2:10][NH2:11])(=[O:3])[CH3:1]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 3-(2-methyl-1,3-dioxolan-2-yl)benzylamine (57.2 g) in 1N hydrochloric acid (500 ml) and methanol (500 ml) was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure. The residue was dissolved in methanol. The resulting precipitate was removed by filtration. The solvent was removed under reduced pressure. Recrystallization from a mixture of ethanol and acetone afforded 3-acetylbenzylamine hydrochloride (31.2 g).
Workup
- customThe solvent was removed under reduced pressure
- dissolutionThe residue was dissolved in methanol
- customThe resulting precipitate was removed by filtration
- customThe solvent was removed under reduced pressure
- customRecrystallization
- additionfrom a mixture of ethanol and acetone
Sources & evidence
- ORD record
- ord-205cfc1d3f0f472e8b6e80b5f4dff919
- Source dataset
- uspto-grants-1996_07
- Patent number
- US05532258
Reaction notes
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