Dimethylformamide dimethyl acetal → HCID 136000308, compound
Reaction equation
CO[CH:3](OC)[N:4]([CH3:6])[CH3:5].[OH:9][C:10]1[C:11]2[C:15]([CH:16]=[CH:17][CH:18]=1)=[N:14][N:13]([CH3:19])[C:12]=2[S:20]([NH2:23])(=[O:22])=[O:21]>C(#N)C>[CH3:6][N:4]([CH3:5])[CH:3]=[N:23][S:20]([C:12]1[N:13]([CH3:19])[N:14]=[C:15]2[C:11]=1[C:10]([OH:9])=[CH:18][CH:17]=[CH:16]2)(=[O:21])=[O:22]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
21.3 g (174 mmol) of dimethylformamide dimethylacetal was dropwise added to a solution containing 33 g (145 mmol) of 4-hydroxy-2-methyl-2H-indazole-3-sulfonamide in 200 ml of acetonitrile, at room temperature. The mixture was stirred for one hour, then poured into ice water and extracted with ethyl acetate. The organic layer was washed with water, then concentrated and purified by column chromatography to obtain 35.2 g (yield: 86.3%) of the desired product. Melting point: 118°-119° C.