Potassium Hydroxide → Phosphorothioic acid, O,O-dipropyl ester, potassium salt
Reaction equation
[CH2:1]([O:4][P:5](Cl)([O:7][CH2:8][CH2:9][CH3:10])=[S:6])[CH2:2][CH3:3].[OH-:12].[K+:13]>C(O)CC>[K+:13].[P:5]([O-:12])([O:7][CH2:8][CH2:9][CH3:10])([O:4][CH2:1][CH2:2][CH3:3])=[S:6]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To 100 g (460 mmole) of di-n-propylchlorothiophosphate in 300 ml of 1-propanol was added 58.8 g (920 mmole) of 88% potassium hydroxide pellets. The reaction mixture was refluxed overnight and then cooled to room temperature. The precipitated potassium chloride was filtered off and the solvent was stripped in vacuo. The resulting solid was slurried in 20% diethyl ether/80% hexanes and filtered yielding 67 g of the title compound, a fluffy white solid, mp 205°-207° C.
Workup
- temperatureThe reaction mixture was refluxed overnight
- filtrationThe precipitated potassium chloride was filtered off
- filtrationfiltered
Sources & evidence
- ORD record
- ord-3760ece89e10404795776864ab90dcb6
- Source dataset
- uspto-grants-1996_07
- Patent number
- US05536711
Reaction notes
Loading…