Diethyl Ether → Diethyl 2-fluoro-2-phenylmalonate

HRID 173700

Reaction equation

HRID 173700 reaction equation
[CH3:50][C:51]#[N:52].[CH3:53][CH2:54][O:55][CH2:56][CH3:57].[F:40][N+:41]12[CH2:42][CH2:43][N+:44]([F:45])([CH2:46][CH2:47]1)[CH2:48][CH2:49]2.[Na:1][C:2]([C:3](=[O:4])[O:5][CH2:6][CH3:7])([C:8](=[O:9])[O:10][CH2:11][CH3:12])[c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1.[O:19]1[CH2:20][CH2:21][CH2:22][CH2:23]1.[S:24]([O-:25])([C:26]([F:27])([F:28])[F:29])(=[O:30])=[O:31].[S:32]([O-:33])([C:34]([F:35])([F:36])[F:37])(=[O:38])=[O:39]>>[C:2]([C:3](=[O:4])[O:5][CH2:6][CH3:7])([C:8](=[O:9])[O:10][CH2:11][CH3:12])([c:13]1[cH:14][cH:15][cH:16][cH:17][cH:18]1)[F:28]

Participants

7

Reactant 6

HCID 3283Diethyl EtherHCID 6342AcetonitrileHCID 8028TetrahydrofuranHCID 2758875Trifluoromethanesulfonate2×HCID 10980844HCID 10980844, compoundHCID 178472663C13H15NaO4

Product 1

HCID 4246642Diethyl 2-fluoro-2-phenylmalonate

Sources & evidence

ORD record
ord-2022469c8cd541c0a7d3249c99a9f888
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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