Dichloromethane → 2-chloro-5,6a-dimethyl-4-morpholino-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-6(5H)-one

Reaction equation

[CH2:27]1[CH2:28][O:29][CH2:30][CH2:31][NH:32]1.[CH3:20][CH2:21][N:22]([CH2:23][CH3:24])[CH2:25][CH3:26].[Cl:1][c:2]1[n:3][c:4]2[c:9]([c:10]([Cl:12])[n:11]1)[N:8]([CH3:13])[C:7](=[O:14])[C:6]1([CH3:19])[N:5]2[CH2:18][CH2:17][O:16][CH2:15]1.[Cl:33][CH2:34][Cl:35]>>[Cl:1][c:2]1[n:3][c:4]2[c:9]([c:10]([N:32]3[CH2:27][CH2:28][O:29][CH2:30][CH2:31]3)[n:11]1)[N:8]([CH3:13])[C:7](=[O:14])[C:6]1([CH3:19])[N:5]2[CH2:18][CH2:17][O:16][CH2:15]1

Participants

Reactant 4

HCID 6344Dichloromethane

HCID 8083Morpholine

HCID 8471Triethylamine

HCID 866515672,4-dichloro-5,6a-dimethyl-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-6(5H)-one

Product 1

HCID 866515682-chloro-5,6a-dimethyl-4-morpholino-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-6(5H)-one

Sources & evidence

ORD record: ord-e3ec9815ba8f4b1083730c3585d4cc24
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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