Nitric Acid → 4-Amino-3-nitropyridine

HRID 1739760

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[N+:13]([O-])([OH:15])=[O:14].NC1C([N+]([O-])=O)=NC=CC=1.NC(C)C#N>>[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N+:13]([O-:15])=[O:14]

Participants

Reactant 5

HCID 944Nitric Acid

HCID 1118Sulfuric Acid

HCID 17274-Aminopyridine

HCID 832812-Nitropyridin-3-amine

HCID 411840Propanenitrile, 2-amino-

Product 1

HCID 5488034-Amino-3-nitropyridine

Procedure

4-Amino-3-nitropyridine was synthesized by a literature reference [Harris M. G. and Stewart R. Can. J. Chem. 55, 3800 (1977)]; by nitration of 4-aminopyridine with conc. sulfuric acid and fuming nitric acid. This aminonitropyridine was then converted to the aminopropionitrile derivative IV by the method described in Example 1.

Sources & evidence

ORD record: ord-43f197b3e3d046e6af821251aff2b1c6
Source dataset: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05968946

Linked notes

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