Potassium Hydroxide → HCID 10197851, compound

HRID 1740985

Reaction equation

HRID 1740985 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH2:8][CH:9]([CH3:11])[CH3:10])[N:5]=[C:4]([N:12]2C(C)=CC=C2C)[CH:3]=1.Cl.NO.[OH-].[K+]>C(O)C.O>[NH2:12][C:4]1[CH:3]=[C:2]([CH3:1])[CH:7]=[C:6]([CH2:8][CH:9]([CH3:11])[CH3:10])[N:5]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 218344234-Methyl-6-(2-methylpropyl)-2-(2,5-dimethylpyrrol-1-yl)pyridine

Product 1

HCID 10197851HCID 10197851, compound

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

By analogy to Example 56, Step B, 4-methyl-6-(2-methylpropyl)-2-(2,5-dimethylpyrrol-1-yl)pyridine was treated with 4.6 equivalents of hydroxylamine hydrochloride and 2.8 equivalents of potassium hydroxide in refluxing ethanol/water to yield 2-amino-4-methyl-6-(2-methylpropyl)pyridine as a white solid.

Sources & evidence

ORD record
ord-09b13538117449c695ca3cd8be255ada
Source dataset
uspto-grants-1999_10
Patent number
US05972975

Linked notes

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