Diisobutylaluminum hydride → 3-(2-Pyridyl)-2-propen-1-ol
Reaction equation
CC(C[AlH]CC(C)C)C.[N:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1/[CH:16]=[CH:17]/[C:18](OCC)=[O:19]>C1(C)C=CC=CC=1>[N:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1/[CH:16]=[CH:17]/[CH2:18][OH:19]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
As in Example 3, Step 2, but using a 1.5M solution of DIBAL in toluene, the ester from Step 1 of the present example was converted to the title compound. The alcohol was chromatographed on silica using EtOAc/toluene (9:1) as eluent.
Sources & evidence
- ORD record
- ord-8c2846b9ad0c48d890b85d4f80be9722
- Source dataset
- uspto-grants-1994_08
- Patent number
- US05334597
Reaction notes
Loading…