Ethyl isocyanate → 4-Ethyl-2-propyl semicarbazide

HRID 1741864

Reaction equation

HRID 1741864 reaction equation
C(O)(=O)C(O)=O.[CH2:7]([NH:10][NH2:11])[CH2:8][CH3:9].C(=O)([O-])[O-].[Na+].[Na+].[CH2:18]([N:20]=[C:21]=[O:22])[CH3:19]>O.O1CCCC1>[CH2:18]([NH:20][C:21](=[O:22])[N:10]([CH2:7][CH2:8][CH3:9])[NH2:11])[CH3:19]

Participants

6

Reactant 3

HCID 8022Ethyl isocyanateHCID 10340Sodium CarbonateHCID 96079Hydrazine, propyl-, ethanedioate (1:1)

Product 1

HCID 190109294-Ethyl-2-propyl semicarbazide

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a stirred slurry of 3.35 g (20 mmol) of n-propylhydrazine oxalate and 2.24 g (20 mmol) of sodium carbonate in 50 mL of water and 10 mL of tetrahydrofuran (THF) was added 1.7 mL (21.5 mmol) of ethyl isocyanate. The mixture was stirred at room temperature for 16 h and evaporated in vacuo to leave crude 4-ethyl-2-propyl semicarbazide as a white solid.

Workup

  1. customevaporated in vacuo

Sources & evidence

ORD record
ord-5f57321e62a6428397dbd99332e3be1a
Source dataset
uspto-grants-1994_08
Patent number
US05334726

Linked notes

Loading…