Butylamine → 3-n-Butylaminopyridin-2-ylsulfonamide

HRID 1742073

Reaction equation

HRID 1742073 reaction equation
[CH2:1]([NH2:5])[CH2:2][CH2:3][CH3:4].F[C:7]1[C:8]([S:13]([NH2:16])(=[O:15])=[O:14])=[N:9][CH:10]=[CH:11][CH:12]=1>O1CCCC1>[CH2:1]([NH:5][C:7]1[C:8]([S:13]([NH2:16])(=[O:15])=[O:14])=[N:9][CH:10]=[CH:11][CH:12]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 8007ButylamineHCID 199579303-Fluoropyridine-2-sulfonamide

Product 1

HCID 190099643-n-Butylaminopyridin-2-ylsulfonamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

49.6 ml of n-butylamine are added to a mixture of 8.81 g of 3-fluoropyridin-2-ylsulfonamide in 10 ml of tetrahydrofuran (THF). After the reaction mixture has been stirred for 18 hours at a temperature of 60° C., the reaction mixture is evaporated, the oily residue is triturated with 100 ml of ice/water, the mixture is filtered, and the filtrate is washed first with a little cold water and subsequently with n-hexane. After drying at a temperature of 45° C. in vacuo, 8.8 g of 3-n-butylaminopyridin-2-ylsulfonamide (intermediate No. 2.001) of a melting point of 100°-101° C. are obtained.

Workup

  1. customthe reaction mixture is evaporated
  2. customthe oily residue is triturated with 100 ml of ice/water
  3. filtrationthe mixture is filtered
  4. washthe filtrate is washed first with a little cold water and subsequently with n-hexane
  5. dry with materialAfter drying at a temperature of 45° C. in vacuo, 8.8 g of 3-n-butylaminopyridin-2-ylsulfonamide (intermediate No. 2.001) of a melting point of 100°-101° C.
  6. customare obtained

Sources & evidence

ORD record
ord-307a167ac53a4bedb1de1aaa51c90a43
Source dataset
uspto-grants-1994_08
Patent number
US05336773

Linked notes

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