1-Methylpiperazine → 1-Methyl-4-[4-nitro-2-(trifluoromethyl)phenyl]piperazine

HRID 1746152

Reaction equation

HRID 1746152 reaction equation
F[C:2]1([N+:12]([O-:14])=[O:13])[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][CH2:3]1.[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>CO.O>[CH3:15][N:16]1[CH2:21][CH2:20][N:19]([C:5]2[CH:4]=[CH:3][C:2]([N+:12]([O-:14])=[O:13])=[CH:7][C:6]=2[C:8]([F:11])([F:10])[F:9])[CH2:18][CH2:17]1

Participants

5

Reactant 2

HCID 531671-MethylpiperazineHCID 1317335435-Fluoro-5-nitrobenzotrifluoride

Product 1

HCID 31280181-Methyl-4-[4-nitro-2-(trifluoromethyl)phenyl]piperazine

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

5-Fluoro-5-nitrobenzotrifluoride (2 g) and 1-methylpiperazine (2 mL) were dissolved in methanol (5 mL). The yellow solution was stirred at rt overnight. The reaction mixture was diluted with water (100 mL) and extracted with ethyl acetate (2×100 mL). The organic solutions were evaporated to give 2-(4-methylpiperazino)-5-nitrobenzotrifluoride.

Workup

  1. extractionextracted with ethyl acetate (2×100 mL)
  2. customThe organic solutions were evaporated

Sources & evidence

ORD record
ord-c93388fe6f324de6bab8b8e47fdf79a8
Source dataset
uspto-grants-2015_10
Patent number
US09149475B2

Linked notes

Loading…