[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([CH2:11][N:12]3[C:16]4[CH:17]=[CH:18][C:19]([CH3:21])=[CH:20][C:15]=4[N:14](C(C)=C)[C:13]3=[O:25])[CH:10]=1)[N:7]([CH3:26])[C:6]([CH3:27])=[C:5]2[CH3:28].Cl>CO.O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([CH2:11][N:12]3[C:16]4[CH:17]=[CH:18][C:19]([CH3:21])=[CH:20][C:15]=4[NH:14][C:13]3=[O:25])[CH:10]=1)[N:7]([CH3:26])[C:6]([CH3:27])=[C:5]2[CH3:28]To a solution of 1-(5-Chloro-1,2,3-trimethyl-1H-indol-7-ylmethyl)-3-isopropenyl-5-methyl-1,3-dihydro-benzimidazol-2-one (60 mg, 0.15 mmol) in a mixture of MeOH (3 mL) and water (3 mL), was added 1N HCl (2 mL). The reaction mixture was heated to 60° C. for 2 h. When the reaction was completed, the mixture was extracted with CH2Cl2 (×2). The organic phase was dried over Na2SO4 and concentrated to afford 40 mg of the desired product. The resulting residue was used for the next reaction without further purification.
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