Potassium Carbonate → 7-Methylbenzofuran-3(2H)-one
Reaction equation
Cl[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[C:6]=1[OH:12])=[O:4].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH3:11][C:7]1[C:6]2[O:12][CH2:2][C:3](=[O:4])[C:5]=2[CH:10]=[CH:9][CH:8]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 2-chloro-1-(2-hydroxy-3-methylphenyl)ethanone (Tetrahedron, Vol. 66, p. 3499, 2010, 6.40 g, 34.7 mmol) in acetonitrile (170 mL) was added with potassium carbonate (14.4 g, 104 mmol), and the mixture was stirred at room temperature for 1 hour, and then filtered. The filtrate was concentrated, and the resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate) to obtain 7-methylbenzofuran-3(2H)-one (2.23 g, 43%).
Workup
- filtrationfiltered
- concentrationThe filtrate was concentrated
- customthe resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate)
Sources & evidence
- ORD record
- ord-0651c0a9ffae4ffb951324e378b3c85f
- Source dataset
- uspto-grants-2015_10
- Patent number
- US09156827B2
Reaction notes
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