Dichloromethane → 4-[1-(2-Dimethylamino-acetyl)-piperidin-4-yl]-phenylamine

Reaction equation

[C:1]([O:2][C:3](=[O:4])[NH:7][c:8]1[cH:9][cH:10][c:11]([CH:14]2[CH2:15][CH2:16][N:17]([C:20]([CH2:21][N:22]([CH3:23])[CH3:24])=[O:25])[CH2:18][CH2:19]2)[cH:12][cH:13]1)([CH3:5])([CH3:6])[CH3:26].[Cl:34][CH2:35][Cl:36].[F:27][C:28]([F:29])([F:30])[C:31]([OH:32])=[O:33]>>[NH2:7][c:8]1[cH:9][cH:10][c:11]([CH:14]2[CH2:15][CH2:16][N:17]([C:20]([CH2:21][N:22]([CH3:23])[CH3:24])=[O:25])[CH2:18][CH2:19]2)[cH:12][cH:13]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 68679986{4-[1-(2-Dimethylamino-acetyl)-piperidin-4-yl]-phenyl}-carbamic acid tert-butyl ester

Product 1

HCID 686774374-[1-(2-Dimethylamino-acetyl)-piperidin-4-yl]-phenylamine

Sources & evidence

ORD record: ord-babb4bb6ab25477aa9144891044f252b
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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