1-Butanol → 6-Butoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid

HRID 175328

Reaction equation

HRID 175328 reaction equation
[CH2:1]([CH2:2][CH3:3])[O:4][c:5]1[c:6]([N:14]2[CH2:15][CH2:16][CH2:17][CH2:18]2)[n:7][cH:8][c:9]([C:11](=[O:12])[OH:13])[n:10]1.[CH2:31]1[CH2:32][NH:33][CH2:34][CH2:35]1.[CH2:38]([OH:39])[CH2:40][CH2:41][CH3:42].[CH3:19][O:20][C:21]([c:22]1[cH:23][n:24][c:25]([Cl:26])[c:27]([Br:28])[n:29]1)=[O:30].[K+:37].[OH-:36]>>[CH2:1]([CH2:2][CH2:3][CH3:19])[O:4][c:5]1[c:6]([N:14]2[CH2:15][CH2:16][CH2:17][CH2:18]2)[n:7][cH:8][c:9]([C:11](=[O:12])[OH:13])[n:10]1

Participants

7

Reactant 6

HCID 2631-ButanolHCID 813Potassium CationHCID 961HydroxideHCID 31268PyrrolidineHCID 59254839Methyl 6-bromo-5-chloro-2-pyrazinecarboxylateHCID 685674456-Propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid

Product 1

HCID 685703296-Butoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid

Sources & evidence

ORD record
ord-0a2a84576556492eaf9faafe2c121c15
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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