4-Pyrrolidinopyridine → 4-Hydrazino-6-(4-pyrrolidin-1-ylpiperidin-1-yl)pyrimidine

HRID 1753805Notes

Reaction equation

HRID 1753805 reaction equation
Cl[C:2]1[CH:7]=[C:6]([NH:8][NH2:9])[N:5]=[CH:4][N:3]=1.[N:10]1([C:15]2[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=2)[CH2:14][CH2:13][CH2:12][CH2:11]1>O>[NH:8]([C:6]1[CH:7]=[C:2]([N:18]2[CH2:19][CH2:20][CH:15]([N:10]3[CH2:14][CH2:13][CH2:12][CH2:11]3)[CH2:16][CH2:17]2)[N:3]=[CH:4][N:5]=1)[NH2:9]

Participants

4

Reactant 2

HCID 755674-PyrrolidinopyridineHCID 2472224-Chloro-6-hydrazinylpyrimidine

Product 1

HCID 596037004-Hydrazino-6-(4-pyrrolidin-1-ylpiperidin-1-yl)pyrimidine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 2.0 g (13.8 mmol) of the compound from Example 7A and 4.3 g (27.7 mmol) 4-pyrrolidin-1-ylpyridine is stirred in 20 ml water at 100° C. for 16 h. The solid which has precipitated out is filtered off, washed first with ethanol and then with diethyl ether and dried in vacuo.

Workup

  1. customThe solid which has precipitated out
  2. filtrationis filtered off
  3. washwashed first with ethanol
  4. dry with materialwith diethyl ether and dried in vacuo

Sources & evidence

ORD record
ord-a5d3caab4cc24a7aae1f6c16ab355b33
Source dataset
uspto-grants-2015_10
Patent number
US09168249B2

Reaction notes

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