HCID 54593425, compound → HCID 25156989, compound
Reaction equation
[NH2:1][C:2]1[C:12]([CH3:13])=[CH:11][C:10](Br)=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].[Cu](C#N)[C:16]#[N:17]>CN(C)C(=O)C>[NH2:1][C:2]1[C:12]([CH3:13])=[CH:11][C:10]([C:16]#[N:17])=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The above-described method (Example 2) was repeated to react ethyl 2-amino-5-bromo-3-methylbenzoate (2.00 g, 7.65 mmol) with copper cyanide (0.70 g, 7.80 mmol) in N,N-dimethylacetamide at 160° C. for 8 hours. Following working up similar to Example 2, ethyl 2-amino-5-cyano-3-methylbenzoate (1.30 g, 80.2% of theory, 96.3 area % LC) was obtained as a brown solid.
Sources & evidence
- ORD record
- ord-49baf5ececd54d2697adf98b7b9ffd0d
- Source dataset
- uspto-grants-2015_10
- Patent number
- US09169198B2
Reaction notes
Loading…