Hydrochloric Acid → 3-amino-4-methyl-pentan-2-one
Reaction equation
C([NH:4][CH:5]([CH:9]([CH3:11])[CH3:10])[C:6](=[O:8])[CH3:7])(=O)C.[ClH:12]>C(O)C>[ClH:12].[O:8]=[C:6]([CH:5]([NH2:4])[CH:9]([CH3:11])[CH3:10])[CH3:7]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of N-acetyl-2-keto-3-amino-4-methylpentane (6.33 g, 40.3 mmol) and 6M hydrochloric acid (65 ml) was heated at reflux overnight. The reaction mixture was cooled to room temperature, ethanol (100 ml) was added and the mixture concentrated under reduced pressure. The mixture wastriturated with ether to give a precipitate which was collected by filtration. Crystallisation from acetone gave 2-keto-3-amino-4-methylpentane hydrochloride (2.9 g, 63%) as a white crystalline solid.
Workup
- temperaturewas heated
- temperatureat reflux overnight
- concentrationthe mixture concentrated under reduced pressure
- customto give a precipitate which
- filtrationwas collected by filtration
- customCrystallisation from acetone
Sources & evidence
- ORD record
- ord-20cac4779c2844f79173efd66edf5f6a
- Source dataset
- uspto-grants-1995_08
- Patent number
- US05446032
Reaction notes
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