Hydrochloric Acid → 1-(4-Nitrophenyl)ethan-1-amine hydrochloride

HRID 1759458

Reaction equation

HRID 1759458 reaction equation
[N+:1]([C:4]1[CH:12]=[CH:11][C:7]([CH:8]([NH2:10])[CH3:9])=[CH:6][CH:5]=1)([O-:3])=[O:2].[ClH:13]>>[ClH:13].[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH:8]([NH2:10])[CH3:9])=[CH:11][CH:12]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 5919951-(4-Nitrophenyl)ethanamine

Product 1

HCID 219596521-(4-Nitrophenyl)ethan-1-amine hydrochloride

Procedure

The mother liquors of the solution of the partially resolved (+)-erythrochlorocitric acid, bis-(-)-p-nitro-α-methylbenzylamine salt were treated with 13 ml (0.52 mol) of conc hydrochloric acid and evaporated to dryness. 1,2-Dimethoxyethane was added and the solution was evaporated to dryness. Ether was added to the residue, the mixture was stirred and the precipitate was collected to afford 29.2 g of (-)-p-nitro-α-methylbenzylamine hydrochloride.

Workup

  1. customevaporated to dryness
  2. addition1,2-Dimethoxyethane was added
  3. customthe solution was evaporated to dryness
  4. additionEther was added to the residue
  5. customthe precipitate was collected

Sources & evidence

ORD record
ord-2ef320c6c71147cea99b1b0eec6a332d
Source dataset
uspto-grants-1982_07
Patent number
US04340754

Linked notes

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