Sodium → HCID 14552385, compound
Reaction equation
[Na].[CH2:2]([O:4][C:5]([CH:7]1[CH:16]([NH2:17])[CH2:15][CH2:14][C:9]2([O:13][CH2:12][CH2:11][O:10]2)[CH2:8]1)=[O:6])[CH3:3]>C(O)C>[NH2:17][C@@H:16]1[CH2:15][CH2:14][C:9]2([O:13][CH2:12][CH2:11][O:10]2)[CH2:8][C@H:7]1[C:5]([O:4][CH2:2][CH3:3])=[O:6]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Sodium metal (27.7 g, 1.2 mole) was reacted with ethanol (1 l), then ethyl-8-amino-1,4-dioxaspiro[4.5]-decane-7-carboxylate (137.7 g, 0.6 mole) in ethanol (400 ml) was added. The mixture was refluxed for 11/2 hours, then cooled to room temperature, poured into ice, and made basic. The product was extracted with methylene chloride, dried with sodium sulfate and evaporated to give 118.0 g (85.7%) of the title product.
Workup
- temperatureThe mixture was refluxed for 11/2 hours
- additionpoured into ice
- extractionThe product was extracted with methylene chloride
- dry with materialdried with sodium sulfate
- customevaporated
Sources & evidence
- ORD record
- ord-e241bc59f9314ae7bba66457b95fd975
- Source dataset
- uspto-grants-1989_05
- Patent number
- US04826986
Reaction notes
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