Hydrazine hydrate (1:1) → 4-Chlorophenyl 1-(1, 2, 4-triazol-1-yl)-cyclopropyl ketone hydrazone
Reaction equation
[N:1]1([C:6]2([C:9]([C:11]3[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=3)=O)[CH2:8][CH2:7]2)[CH:5]=[N:4][CH:3]=[N:2]1.O.[NH2:19][NH2:20]>C(O)C>[N:1]1([C:6]2([C:9](=[N:19][NH2:20])[C:11]3[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=3)[CH2:8][CH2:7]2)[CH:5]=[N:4][CH:3]=[N:2]1Participants
4
Procedure
37.1 g (0.15 mol) of 4-chlorophenyl 1-(1, 2, 4-triazol-1-yl)-cyclopropyl ketone were refluxed for 6 hours with 37.5 g (0.3 mol) of 80% strength hydrazine hydrate in 150 ml of ethanol. After removing the solvent by distillation in vacuo, 38.5 g (98%) of the title compound were obtained as a yellow oil.
Workup
- customAfter removing the solvent
- distillationby distillation in vacuo
Sources & evidence
- ORD record
- ord-6379244c88304b11ba5680509452e2c3
- Source dataset
- uspto-grants-1989_05
- Patent number
- US04829075
Reaction notes
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