2-Amino-2-methyl-1,3-propanediol → HCID 54456448, compound

HRID 1762009

Reaction equation

HRID 1762009 reaction equation
[CH3:1][S:2]([O:5][CH2:6][C:7]([NH:11][CH2:12][C:13]1[CH:14]=[C:15]2[C:24](=[C:25]3[C:30]=1[CH:29]=[CH:28][CH:27]=[CH:26]3)[CH:23]=[CH:22][C:21]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]2=1)([CH3:10])[CH2:8][OH:9])(=[O:4])=[O:3].[CH2:31](C1C2C=CC=CC=2C2C(=C3C(=C(C=O)C=2)C=CC=C3)C=1)[CH3:32].NC(C)(CO)CO>>[CH3:1][S:2]([O:5][CH2:6][C:7]([NH:11][CH2:12][C:13]1[CH:14]=[C:15]2[C:24](=[C:25]3[C:30]=1[CH:29]=[CH:28][CH:27]=[CH:26]3)[CH:23]=[C:22]([CH2:31][CH3:32])[C:21]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]2=1)([CH3:10])[CH2:8][OH:9])(=[O:4])=[O:3]

Participants

4

Reactant 3

HCID 15312-Amino-2-methyl-1,3-propanediolHCID 1337539012-Ethyl-6-chrysenecarbaldehydeHCID 540960872-((6-Chrysenylmethyl)amino)-2-methyl-1,3-propanediol methanesulfonate

Product 1

HCID 54456448HCID 54456448, compound

Procedure

Using the reductive amination procedure outlined in 1C, 12-ethyl-6-chrysenecarbaldehyde (15A) and 2-amino-2-methyl-1,3-propanediol (Aldrich) gave 2-(((12-ethyl-6-chrysenyl)methyl)amino)-2-methyl-1,3-propanediol methanesulfonate mp 189°-192° (dec), (EtOH/Et2O), (C,H,N,S).

Sources & evidence

ORD record
ord-6f05916391104881a1b585675fcb4e3c
Source dataset
uspto-grants-1989_05
Patent number
US04829090

Linked notes

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