P-Cresol → HCID 4115019, compound

Reaction equation

[CH:1]1[C:6]([OH:7])=[CH:5][CH:4]=[C:3]([CH3:8])[CH:2]=1.[C:9]1(=[O:15])[O:14][C:12](=[O:13])[CH2:11][CH2:10]1.[Cl-].[Al+3].[Cl-].[Cl-]>>[CH3:8][C:3]1[CH:2]=[CH:1][C:6]([OH:7])=[C:5]([CH:4]=1)[C:9]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[O:15]

Participants

Reactant 3

HCID 2879P-Cresol

HCID 7922Succinic anhydride

HCID 6451240Aluminum(III) Chloride

Product 1

HCID 4115019HCID 4115019, compound

Procedure

p-Cresol was reacted with succinic anhydride and aluminium chloride in a similar manner to the procedure described in Example 8 (i) to give 3-(5-methyl-2-hydroxybenzoyl)-propionic acid.

Sources & evidence

ORD record: ord-9360314662b846e89d618ffcc598c94a
Source dataset: uspto-grants-1978_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04111936

Reaction notes

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