Acetic Acid → HCID 20310586, compound
Reaction equation
[C:1]([C:3]1[CH:17]=[CH:16][C:6]2[CH:7]=[CH:8][N:9]3[CH:15]=[CH:14][CH:13]=[C:10]3[C:11](=[O:12])[C:5]=2[CH:4]=1)#[N:2].Cl.C(O)(=[O:21])C>>[C:1]([C:3]1[CH:17]=[CH:16][C:6]2[CH:7]=[CH:8][N:9]3[CH:15]=[CH:14][CH:13]=[C:10]3[C:11](=[O:12])[C:5]=2[CH:4]=1)(=[O:21])[NH2:2]Participants
4
Procedure
9-Cyano-11H-pyrrolo[2,1-b][3]benzazepin-11-one (30 g., 0.135 mole) in 100 ml. of concentrated hydrochloric acid and 100 ml. of acetic acid is refluxed for 2 hours. It is then poured onto 500 ml. of water and continuously extracted with methylene chloride. The solution is left to cool to room temperature and filtered to afford 9-carbamoyl-11H-pyrrolo[2,1-b][3]benzazepin-11-one.
Workup
- additionIt is then poured onto 500 ml
- extractionof water and continuously extracted with methylene chloride