Hydrochloric Acid → O-Methyltyrosine

HRID 1763740

Reaction equation

HRID 1763740 reaction equation
[CH3:1][O:2][C:3]1[CH:16]=[CH:15][C:6]([CH2:7][CH:8]2[NH:12]C(=O)N[C:9]2=[O:14])=[CH:5][CH:4]=1.[OH-:17].[Na+].Cl>O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][CH:8]([C:9]([OH:14])=[O:17])[NH2:12])=[CH:15][CH:16]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 957275-(4-Methoxy-benzyl)-hydantoin

Product 1

HCID 97118O-Methyltyrosine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 148 g. of 5-p-methoxybenzyl hydantoin and 188 g. of sodium hydroxide in one liter of water is heated at reflux for 25 hours. The solution is cooled and made acid to pH 1 with concentrated hydrochloric acid. The formed solid is separated by filtration, washed with water and dried to give the above named compound, mp. 255° C. dec.

Workup

  1. temperatureat reflux for 25 hours
  2. temperatureThe solution is cooled
  3. customThe formed solid is separated by filtration
  4. washwashed with water
  5. customdried
  6. customto give the

Sources & evidence

ORD record
ord-ad2f9784c50e47a380a258bb024a23b0
Source dataset
uspto-grants-1978_09
Patent number
US04111923

Linked notes

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