Salicylamide → 2,3-Dihydro-2-methyl-4H-1,3-benzoxazin-4-one

HRID 1767603Notes

Reaction equation

[OH:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[CH3:11][CH:12]1OC(C)OC(C)O1>>[CH3:11][CH:12]1[NH:6][C:4](=[O:5])[C:3]2[CH:7]=[CH:8][CH:9]=[CH:10][C:2]=2[O:1]1

Participants

Reactant 2

HCID 5147Salicylamide

HCID 31264Paraldehyde

Product 1

HCID 301992,3-Dihydro-2-methyl-4H-1,3-benzoxazin-4-one

Procedure

2-Hydroxybenzamide was transformed by Method G (using paraldehyde). M.p. 124–126° C.

Sources & evidence

ORD record: ord-8a4a25ab78dc4d438cff75ef49ffb30c
Source dataset: uspto-grants-2007_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07235548B2

Reaction notes

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