Methanol → 2-Chloro-4-(5-methylthiophen-2-yl)pyrimidine

HRID 176919

Reaction equation

HRID 176919 reaction equation
[C:18](=[O:19])([O-:20])[O-:21].[CH3:1][c:2]1[cH:3][cH:4][c:5]([B:7]([OH:8])[OH:9])[s:6]1.[CH3:24][C:25]#[N:26].[CH3:30][OH:31].[Cl:10][c:11]1[n:12][cH:13][cH:14][c:15]([Cl:17])[n:16]1.[Cl:27][CH2:28][Cl:29].[Na+:22].[Na+:23]>>[CH3:1][c:2]1[cH:3][cH:4][c:5](-[c:15]2[cH:14][cH:13][n:12][c:11]([Cl:10])[n:16]2)[s:6]1

Participants

8

Reactant 7

HCID 887MethanolHCID 923Sodium ion2×HCID 6342AcetonitrileHCID 6344DichloromethaneHCID 19660Carbonate IonHCID 775312,4-DichloropyrimidineHCID 2734374(5-Methylthiophen-2-yl)boronic acid

Product 1

HCID 574288352-Chloro-4-(5-methylthiophen-2-yl)pyrimidine

Sources & evidence

ORD record
ord-4b5d489f17b240438a1fa99978a647b8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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